Alkaline-extracted influenza subunit vaccine
نویسندگان
چکیده
منابع مشابه
Preparation and properties of a novel influenza subunit vaccine.
Haemagglutinin and neuraminidase have clearly been shown to be responsible for the stimulation of immunity against influenza. In the approach described, these two immunogens are selectively solubilized, leaving an intact subviral particle which contains lipid and non-protective components. The methods used can readily be adapted to large scale production. The immunogenicity of such antigen-prep...
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Recent studies have demonstrated the effectiveness of vaccine delivery to the skin by vaccine-coated microneedles; however there is little information on the effects of adjuvants using this approach for vaccination. Here we investigate the use of TLR ligands as adjuvants with skin-based delivery of influenza subunit vaccine. BALB/c mice received 1 µg of monovalent H1N1 subunit vaccine alone or ...
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Skin has gained substantial attention as a vaccine target organ due to its immunological properties, which include a high density of professional antigen presenting cells (APCs). Previous studies have demonstrated the effectiveness of this vaccination route not only in animal models but also in adults. Young children represent a population group that is at high risk from influenza infection. As...
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ژورنال
عنوان ژورنال: Infection and Immunity
سال: 1976
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.14.6.1302-1308.1976